Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Design, synthesis and antiproliferative activity of oxadiazole derivatives as potent glycogen synthase kinase-3/histone deacetylase 6 dual inhibitors
doi: 10.1080/14756366.2026.2627711
Figure Lengend Snippet: (A). Effect of compound 15i on the acetylation of histone H3 and α -tubulin in AGS cell line ( n = 3); (B) Densitometry analysis of protein Ac-H3 and Ac- a -tubulin. Data are the average of three independent experiments mean ± SD; ** p < 0.01, *** p < 0.001 indicated comparison with the control group.
Article Snippet: Membranes were blocked with 5% non-fat milk in TBST and subsequently incubated overnight at 4 °C with primary antibodies against Ac-H3 (abcom, AB32129) and Ac- ɑ -tubulin (Cell Signalling, 2144), PARP, Caspase-9, Caspase-3, and GAPDH.
Techniques: Comparison, Control